SINCE World War II, medical science has progressed with a stage where competitive medications are for sale to treat the same ailment in different people. This isn’t nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall go through the various factors that decide selecting a particular drug.

Safety: The subsequent sub-criteria must be considered under the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug even if it has certain side-effects so long as the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the opportunity side-effect of addiction.

* Long-term safety: medicine could possibly be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and several chemicals reply to develop a different chemical, that have an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other person, have certain effects using one or higher body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This makes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually create the same impact on the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both medicine is more intense.

Tolerability: A medication could possibly be effective although not tolerable by all patients. Example: Allergies to certain drugs in some people. Short-term and long-term tolerability must be considered. Efficacy: A medication isn’t equally efficient at all patients. For example, some patients with depression or anxiety disorders experience relief from escitalopram, but there are lots of that don’t, who therefore must be prescribed some other anti-depressant. The rate of start of therapeutic action is an important factor to be looked at too.

Cost: Cost doesn’t imply the price of acquisition of some medicine alone. It should also cover the price of treating a complication that may arise from using some other drug. Example: In a individual who insists on taking alcohol and yet needs to be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (including tricyclics) could cause a fresh overuse injury in such patients, which may require a various and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram instead of a cheaper tricyclic in such patients.

Simplicity of treatment: Most effective mode of administration is preferred. If there is a choice between an injection and oral administration, the latter is preferred in the event the efficacy of both modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are key point to decide simplicity of treatment.
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