SINCE World War II, medical science has progressed to some stage where competitive medications are around to treat the same ailment in several people. It’s not almost brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall glance at the various factors that decide your selection of a particular drug.

Safety: The subsequent sub-criteria has to be considered underneath the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug even when it’s got certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but feature the possibility side-effect of addiction.

* Long-term safety: drug may be safe in short-term treatment, but how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and many chemicals respond to produce a different chemical, which has an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of one another, have certain effects on one or more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This will cause an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually generate the same effect on the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both the prescription medication is more serious.

Tolerability: A drug may be effective however, not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability need to be considered. Efficacy: A drug just isn’t equally great at all patients. For instance, some patients with depression or panic attacks experience reduced escitalopram, but there are several who don’t, who therefore need to be prescribed an alternative anti-depressant. The pace of start of therapeutic action is a vital factor to be regarded as too.

Cost: Cost does not necessarily mean the price of buying a particular medicine alone. It will also cover the price of treatment of a complication that may arise while using an alternative drug. Example: Inside a individual who insists on taking alcohol and yet must be treated for depression is generally administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another number of anti-depressants (like tricyclics) could cause a brand new symptom in such patients, which could require a different and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than a cheaper tricyclic in such patients.

Simple treatment: The simplest mode of administration is preferred. If you have a choice between a shot and oral administration, aforementioned is preferred in the event the efficacy of both the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key point to determine simple treatment.
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