SINCE Wwii, medical science has progressed to a stage where competitive medications are around to treat exactly the same ailment in different people. This isn’t pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall consider the various factors that decide the selection of a certain drug.

Safety: The subsequent sub-criteria have to be considered underneath the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug even when it’s got certain side-effects providing the acuteness from the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the possibility side-effect of addiction.

* Long-term safety: medicationdirectory.com could possibly be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Drugs are chemicals, and a lot of chemicals reply to develop a different chemical, which has an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of 2 types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects one or more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This causes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually make the same relation to exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both the medicines are more intense.

Tolerability: A drug could possibly be effective and not tolerable by all patients. Example: Allergies to certain drugs in some people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A drug just isn’t equally great at all patients. For instance, some patients with depression or anxiety attacks experience respite from escitalopram, but there are numerous that do not, who therefore need to be prescribed a different anti-depressant. The rate of onset of therapeutic action is a crucial step to be regarded too.

Cost: Cost does not necessarily mean the expense of acquisition of some medicine alone. It ought to also cover the expense of treatments for a complication that may arise from utilizing a different drug. Example: Inside a person who insists on taking alcohol but must be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (such as tricyclics) can cause a whole new overuse injury in such patients, which will demand a various and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than cheaper tricyclic in such patients.

Simple treatment: The easiest mode of administration is preferred. If you find a choice between a shot and oral administration, the second is preferred when the efficacy of both the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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