Selective Androgen Receptor Modulators: Existing Insight and Scientific Plans
Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors determined by each SARM’s chemical structure. Therefore, SARMs lead to anabolic cellular activity while avoiding most of the side effects of available today anabolic steroids. SARMs have already been studied in the treating breast cancer and cachexia and have also been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.
Aim
To provide the setting, mechanisms, current and potential clinical applications, in addition to risks and benefits of SARMs.
Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and muscle tissue. Both preliminary research and scientific studies were included.
Main Outcome Measure
To accomplish a review of peer-reviewed literature.
Results
Though there are no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential uses of these compounds. Basic research has devoted to the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability which has a paucity of drug interactions. Early clinical studies have demonstrated potential ways to use SARMs from the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with good success.
Conclusion
SARMs have a lot of possible clinical applications, with promise for the safe used in the treating cachexia, BPH, hypogonadism, breast cancer, and prostate cancer.
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