SINCE Wwii, medical science has progressed with a stage where competitive medications are available to treat exactly the same ailment in several people. This isn’t just about brands (the industry trade issue) but generic drugs (the industry scientific issue). Within this report, we shall go through the various factors that decide your selection of a certain drug.

Safety: The subsequent sub-criteria has to be considered within the criterion of safety:

* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug regardless of whether it has certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but come with the possible side-effect of addiction.

* Long-term safety: medicine may be safe in short-term treatment, but exactly how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and a lot of chemicals answer create a different chemical, which has an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects one or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on due to the metabolism. This makes a boost in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually create the same relation to exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two prescription medication is more intense.

Tolerability: A medication may be effective but not tolerable by all patients. Example: Allergies to particular drugs in most people. Short-term and long-term tolerability must be considered. Efficacy: A medication is not equally good at all patients. For example, some patients with depression or panic disorders experience rest from escitalopram, but there are many that don’t, who therefore must be prescribed a different anti-depressant. The rate of onset of therapeutic action is a crucial the answer to be looked at too.

Cost: Cost does not necessarily mean the cost of buying a particular medicine alone. It will also cover the cost of treatments for a complication that may arise from using a different drug. Example: Inside a one who insists on taking alcohol yet has to be treated for depression is normally administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (such as tricyclics) can cause a new problem in such patients, which would need a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram instead of a cheaper tricyclic in these patients.

Simple treatment: The easiest mode of administration is preferred. If there is an alternative between a shot and oral administration, the latter is preferred in the event the efficacy of the two modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key point to determine simple treatment.
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