SINCE World War II, medical science has progressed to some stage where competitive medications are around to treat precisely the same ailment in numerous people. It’s not just about brands (which is a trade issue) but generic drugs (which is a scientific issue). In this report, we shall look at the various factors that decide picking a a certain drug.

Safety: The next sub-criteria has to be considered under the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even though it has certain side-effects providing the acuteness from the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but have the potential side-effect of addiction.

* Long-term safety: medicine directory could possibly be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and many chemicals respond to produce a different chemical, which has an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This leads to a boost in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually create the same impact on precisely the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the medicines are more serious.

Tolerability: A medicine could possibly be effective although not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability must be considered. Efficacy: A medicine isn’t equally effective in all patients. For example, some patients with depression or panic attacks experience rest from escitalopram, but there are many who don’t, who therefore must be prescribed some other anti-depressant. The pace of beginning of therapeutic action is a crucial the answer to be regarded as too.

Cost: Cost does not necessarily mean the expense of acquiring a specific medicine alone. It must also cover the expense of management of a complication that will arise by using some other drug. Example: Within a individual that insists on taking alcohol and yet has to be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the end results of alcohol, whereas another gang of anti-depressants (including tricyclics) might cause a whole new symptom in such patients, which will need a different and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in these patients.

Simplicity of treatment: The easiest mode of administration is preferred. If there is an alternative between a shot and oral administration, the latter is preferred if your efficacy of both the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are key point to determine simplicity of treatment.
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