SINCE World war 2, medical science has progressed into a stage where competitive medications are available to treat the same ailment in various people. It’s not nearly brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall go through the various factors that decide selecting a specific drug.

Safety: The next sub-criteria have to be considered within the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug even though they have certain side-effects so long as the acuteness with the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but include the opportunity side-effect of addiction.

* Long-term safety: medicine might be safe in short-term treatment, but exactly how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.

* Drug-drug interaction risk: Drugs are chemicals, and lots of chemicals react to develop a different chemical, which has an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from one another, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for its metabolism. This leads to more the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually produce the same impact on the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the two prescription medication is more serious.

Tolerability: A medicine might be effective and not tolerable by all patients. Example: Allergies to a particular drugs in some people. Short-term and long-term tolerability need to be taken into account. Efficacy: A medicine isn’t equally great at all patients. For instance, some patients with depression or anxiety disorders experience rest from escitalopram, but there are several who don’t, who therefore need to be prescribed some other anti-depressant. The speed of oncoming of therapeutic action is a vital the answer to be looked at too.

Cost: Cost does not always mean the price tag on buying a particular medicine alone. It will also cover the price tag on management of a complication that may arise while using some other drug. Example: Inside a one who insists on taking alcohol and yet has to be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (for example tricyclics) could cause a brand new problem in such patients, which would have to have a various and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in this patients.

Simplicity of treatment: The simplest mode of administration is preferred. If you have an option between an injection and oral administration, aforementioned is preferred if the efficacy of the two modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to choose simplicity of treatment.
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