SINCE World War II, medical science has progressed to a stage where competitive medications are for sale to treat the same ailment in different people. This is not pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall consider the various factors that decide selecting a particular drug.

Safety: These sub-criteria have to be considered beneath the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even if it has certain side-effects providing the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but feature the possible side-effect of addiction.

* Long-term safety: medicine directory could be safe in short-term treatment, so how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case there is prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and many chemicals reply to develop a different chemical, that have an effect that will harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from one another, have certain effects using one or more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon for its metabolism. This will cause a boost in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually generate the same relation to the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both medicine is more intense.

Tolerability: A drug could be effective although not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability need to be looked at. Efficacy: A drug isn’t equally great at all patients. By way of example, some patients with depression or anxiety attacks experience reduced escitalopram, but there are many that don’t, who therefore need to be prescribed some other anti-depressant. The interest rate of beginning of therapeutic action is a vital the answer to be looked at too.

Cost: Cost does not always mean the price tag on acquisition of a particular medicine alone. It will also cover the price tag on management of a complication that will arise from utilizing some other drug. Example: In a individual that insists on taking alcohol yet has to be treated for depression is usually administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another gang of anti-depressants (such as tricyclics) can cause a whole new symptom in such patients, which may require a various and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram rather than cheaper tricyclic in such patients.

Simplicity of treatment: The best mode of administration is preferred. When there is an alternative between an injection and oral administration, aforementioned is preferred in the event the efficacy of both modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are key point to decide simple treatment.
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